Abeyance | Preserving Potential
a·bey·ance noun /ɘ-`bā-ɘns/ a temporary state of suspension waiting for claim and use.
Abeyance was founded to help advance wellness by better enabling life science research and therapy. Our goal is to provide innovative cryopreservation cold chain solutions that improve and simplify your workflow. Abeyance refers to a state of temporary suspension waiting for claim and use. We understand successful use of your biospecimen in the laboratory or clinic is the ultimate goal and cryopreservation is a critical link. We strive to produce the easiest to use systems while providing best in class performance and sample security. Our manufacturing capabilities, vertical integration, and experience across the cold chain facilitate a consultative, comprehensive solution. Abeyance is proudly made in the USA with domestic materials and skilled labor. We are dedicated to the highest levels of quality and service to guarantee the best overall cryo customer experience.
What is Cryopreservation?
Cryopreservation is the storage of material below -135°C (-211°F) in order to provide longevity to biospecimens. Around -135°C is referred to as the glass transition point (Tg) of polyol’s water solution. Below Tg, biological activity essentially ceases. At these temperatures, enzymatic activity slows to a stop while frozen water molecules inside cells can no longer move freely and participate in chemical reactions. Current best practices recommend dry storage below -150°C in LN2 vapor for a significant temperature safety margin and to reduce the risk of cross contamination between samples. Specially designed vacuum vessels, or Dewars, are required to provide thermal insulation while accommodating a variety of sample types. Properly preserved biospecimens can be retrieved after decades of storage, successfully reanimated, and be virtually the same physiologically as the day they were frozen.
Why is it Important?
Biospecimens are necessary for life science research, drug discovery, diagnostic testing, and direct therapies with living cells. Temperatures above Tg are typically not sufficient to properly preserve essential biological properties for long term storage. Similar to how your refrigerator prolongs fresh food for days, but storing in your freezer at an even lower temperature extends the shelf life to weeks and months. Once below Tg, biospecimens can be preserved for years and decades.
Advances in technologies such as cell and tissue engineering, gene manipulation, bioprinting, and biofabrication will continue to propel the field of regenerative medicine forward and further necessitate the need for quality biospecimens and the cryopreservation cold chain solutions that make them possible. Not just for long term storage, but also shipping and handling logistics through to bedside delivery.
“The demand for biospecimens – macromolecules, cells, or tissues – is growing rapidly. Therapeutic need is surging as people are treated with cells or tissues to cure a wide variety of diseases. Plus, entirely new therapies are being developed for long standing health concerns, such as cancer. Biospecimens are also being used for diagnostic and epidemiologic purposes — to diagnose diseases, improve blood safety, and monitor treatment progression.
Most biospecimens are collected in one location at a given time, and stored and used at another location at a later time. A blood specimen taken at the doctor’s office may be shipped off and analyzed at a variety of different places. And that healthcare provider is collecting more specimens than ever before. The critical biological properties of that sample must be preserved, or the measurement will not be clinically valid.
The preservation of those samples must be built on scientific principles and protocols. Cryopreservation is a process framed by those scientific principles and not a cold black box. When a sample is placed in a freezer or dewar, it is not magically preserved in pristine condition. Understanding the scientific underpinnings of cryopreservation is critical to understanding and maintaining high-quality biospecimens for whatever application.”